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Stroke Mar 2018
Review
Topics: Animals; Biomedical Research; Humans; Interdisciplinary Communication; Stroke
PubMed: 29438085
DOI: 10.1161/STROKEAHA.117.020437 -
ELife Mar 2020There is a pressing need to increase the rigor of research in the life and biomedical sciences. To address this issue, we propose that communities of 'rigor champions'...
There is a pressing need to increase the rigor of research in the life and biomedical sciences. To address this issue, we propose that communities of 'rigor champions' be established to campaign for reforms of the research culture that has led to shortcomings in rigor. These communities of rigor champions would also assist in the development and adoption of a comprehensive educational platform that would teach the principles of rigorous science to researchers at all career stages.
Topics: Biomedical Research; Humans; Research Design
PubMed: 32127131
DOI: 10.7554/eLife.55915 -
EMBO Reports Feb 2011Forty years ago, Nixon declared war on cancer. Despite enormous efforts, the war is far from won. Instead of retreating from battle, Howy argues that we need more...
Forty years ago, Nixon declared war on cancer. Despite enormous efforts, the war is far from won. Instead of retreating from battle, Howy argues that we need more frontline research to understand the enemy and to overcome its defences.
Topics: Biomedical Research; History, 20th Century; Neoplasms; Politics; Public Policy
PubMed: 21283111
DOI: 10.1038/embor.2010.209 -
Lancet (London, England) Jan 2014After identification of an important research question and selection of an appropriate study design, waste can arise from the regulation, governance, and management of...
After identification of an important research question and selection of an appropriate study design, waste can arise from the regulation, governance, and management of biomedical research. Obtaining regulatory and governance approval has become increasingly burdensome and disproportionate to the conceivable risks to research participants. Regulation and governance involve interventions that are assumed to be justified in the interests of patients and the public, but they can actually compromise these interests. Inefficient management of the procedural conduct of research is wasteful, especially if it results in poor recruitment and retention of participants in well designed studies addressing important questions. These sources of waste can be minimised if the following four recommendations are addressed. First, regulators should use their influence to reduce other causes of waste and inefficiency in research. Second, regulators and policy makers should work with researchers, patients, and health professionals to streamline and harmonise the laws, regulations, guidelines, and processes that govern whether and how research can be done, and ensure that they are proportionate to the plausible risks associated with the research. Third, researchers and research managers should increase the efficiency of recruitment, retention, data monitoring, and data sharing in research through use of research designs known to reduce inefficiencies, and further research should be done to learn how efficiency can be increased. Finally, everyone, particularly those responsible for health-care systems, should promote integration of research into everyday clinical practice. Regulators and researchers should monitor adherence to each of these recommendations and publish metrics.
Topics: Bioethics; Biomedical Research; Research Design
PubMed: 24411646
DOI: 10.1016/S0140-6736(13)62297-7 -
Annals of Oncology : Official Journal... Nov 2011Healthcare outcomes such as overall survival or quality of life are the end results of a complex interaction between the patient, treatment and the healthcare system.... (Review)
Review
Healthcare outcomes such as overall survival or quality of life are the end results of a complex interaction between the patient, treatment and the healthcare system. Research may identify superior interventions but their dissemination and changing the behaviour of healthcare providers is challenging. Demonstrating and measuring the benefits of clinical research on healthcare outcomes is an important issue but there is remarkably little empiric work to date in this area. In this chapter we explore benefits that may arise in healthcare from contributing to clinical research, and consider the mechanisms which may be relevant. Improvements in infrastructure, the processes of care and workforces are important. Complex adaptive systems theory provides a framework for considering the many feedback loops that relate research, health outcomes and the behaviour of healthcare providers. Given the costs of research, additional studies to examine the impact of research on healthcare outcomes and to explore the mechanisms are justified and highly desirable.
Topics: Biomedical Research; Delivery of Health Care; Humans; Outcome Assessment, Health Care; Quality of Health Care
PubMed: 22039138
DOI: 10.1093/annonc/mdr420 -
PLoS Biology Oct 2015As the scientific enterprise has grown in size and diversity, we need empirical evidence on the research process to test and apply interventions that make it more...
As the scientific enterprise has grown in size and diversity, we need empirical evidence on the research process to test and apply interventions that make it more efficient and its results more reliable. Meta-research is an evolving scientific discipline that aims to evaluate and improve research practices. It includes thematic areas of methods, reporting, reproducibility, evaluation, and incentives (how to do, report, verify, correct, and reward science). Much work is already done in this growing field, but efforts to-date are fragmented. We provide a map of ongoing efforts and discuss plans for connecting the multiple meta-research efforts across science worldwide.
Topics: Animals; Biomedical Research; Empirical Research; Evidence-Based Medicine; Guidelines as Topic; Humans; Internationality; Meta-Analysis as Topic
PubMed: 26431313
DOI: 10.1371/journal.pbio.1002264 -
Stroke Aug 2021
Review
Topics: Biomedical Research; Humans; Laboratories; Laboratory Personnel; Leadership; Mentors
PubMed: 34107733
DOI: 10.1161/STROKEAHA.121.035333 -
Protein Science : a Publication of the... Jan 2018The Protein Data Bank (PDB) is one of two archival resources for experimental data central to biomedical research and education worldwide (the other key Primary Data... (Review)
Review
The Protein Data Bank (PDB) is one of two archival resources for experimental data central to biomedical research and education worldwide (the other key Primary Data Archive in biology being the International Nucleotide Sequence Database Collaboration). The PDB currently houses >134,000 atomic level biomolecular structures determined by crystallography, NMR spectroscopy, and 3D electron microscopy. It was established in 1971 as the first open-access, digital-data resource in biology, and is managed by the Worldwide Protein Data Bank partnership (wwPDB; wwpdb.org). US PDB operations are conducted by the RCSB Protein Data Bank (RCSB PDB; RCSB.org; Rutgers University and UC San Diego) and funded by NSF, NIH, and DoE. The RCSB PDB serves as the global Archive Keeper for the wwPDB. During calendar 2016, >591 million structure data files were downloaded from the PDB by Data Consumers working in every sovereign nation recognized by the United Nations. During this same period, the RCSB PDB processed >5300 new atomic level biomolecular structures plus experimental data and metadata coming into the archive from Data Depositors working in the Americas and Oceania. In addition, RCSB PDB served >1 million RCSB.org users worldwide with PDB data integrated with ∼40 external data resources providing rich structural views of fundamental biology, biomedicine, and energy sciences, and >600,000 PDB101.rcsb.org educational website users around the globe. RCSB PDB resources are described in detail together with metrics documenting the impact of access to PDB data on basic and applied research, clinical medicine, education, and the economy.
Topics: Biomedical Research; Databases, Protein; Humans
PubMed: 29067736
DOI: 10.1002/pro.3331 -
Medicina 2014
Topics: Argentina; Biomedical Research; History, 20th Century; History, 21st Century; Humans; Women, Working
PubMed: 24561849
DOI: No ID Found -
Genome Biology Nov 2011
Topics: Biomedical Research; Research Support as Topic
PubMed: 22129215
DOI: 10.1186/gb-2011-12-11-134